Peer-reviewed veterinary case report
Monoclonal antibody against membrane protein of transmissible gastroenteritis virus.
- Journal:
- Monoclonal antibodies in immunodiagnosis and immunotherapy
- Year:
- 2013
- Authors:
- Sun, Xuejiao et al.
- Affiliation:
- College of Veterinary Medicine · China
- Species:
- rodent
Abstract
Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus that can cause piglet diarrhea with high mortality rates. TGEV membrane (M) protein not only plays a vital role in the process of virus assembly and budding, but also induces the production of interferon-α during infection. In this study, a monoclonal antibody (MAb) designated 7G7, against the TGEV M protein was generated by inoculating BALB/c mice with TGEV followed by hybridoma technique. Immunofluorescence assays indicated that MAb 7G7 was capable of detecting cell infection by TGEV. Virus-based ELISA demonstrated that MAb 7G7 can be used as a highly specific diagnostic reagent for TGEV.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23600504/