Peer-reviewed veterinary case report
Molecular epidemiological survey of the Babesia gibsoni cytochrome b gene in western Japan.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2012
- Authors:
- Sakuma, Masato et al.
- Affiliation:
- Joint Faculty of Veterinary Medicine · Japan
- Species:
- dog
Abstract
In this study, we conducted a survey of the cytochrome b (cytb) gene of Babesia gibsoni (B. gibsoni) isolated from clinical cases to determine the prevalence of potential atovaquone (ATV)-resistant variants. Ninety-two blood samples were collected from naturally B. gibsoni infected dogs. The cytb nucleotide sequence was determined by direct sequencing. Twelve non-synonymous amino acid substitutions were identified in cytb. The principal ATV-resistant substitution, M121I, was detected in three cases. This survey determined that potentially ATV-resistant B. gibsoni strains are present in dogs in Japan.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22672842/