Peer-reviewed veterinary case report
Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges.
- Journal:
- Science translational medicine
- Year:
- 2022
- Authors:
- Schmidt, Jenna K et al.
- Affiliation:
- University of Wisconsin-Madison · United States
Abstract
Genetic modification of the embryo or germ line of nonhuman primates is envisioned as a method to develop improved models of human disease, yet the promise of such animal models remains unfulfilled. Here, we discuss current methods and their limitations for producing nonhuman primate genetic models that faithfully genocopy and phenocopy human disease. We reflect on how to ethically maximize the translational relevance of such models in the search for new therapeutic strategies to treat human disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/35235338/