Peer-reviewed veterinary case report
Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research.
- Year:
- 2022
- Authors:
- Deng Z et al.
- Affiliation:
- Department of Radiation Oncology and Molecular Radiation Sciences · United States
Abstract
Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing <i>in vivo</i> soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and <i>in vivo</i> validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.
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Search related cases →Original publication: https://europepmc.org/article/MED/36187243