Peer-reviewed veterinary case report
Mitoxantrone and cyclophosphamide combination chemotherapy for the treatment of various canine malignancies.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 1999
- Authors:
- Henry, C J et al.
- Affiliation:
- Department of Veterinary Medicine and Surgery · United States
- Species:
- dog
Abstract
Thirteen dogs with histopathologically confirmed malignancies were treated with mitoxantrone and cyclophosphamide combination therapy. One to four doses were administered at 21-day intervals. Recombinant human granulocyte colony-stimulating factor was administered to ameliorate myelosuppression in dogs with neutrophil nadirs less than 1,000/microl. While the protocol appears to be safe for use in tumor-bearing dogs, an advantage over mitoxantrone single-agent protocols in terms of tumor response was not demonstrated in this initial pilot study.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/10333263/