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Peer-reviewed veterinary case report

Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.

Journal:
International journal of nanomedicine
Year:
2009
Authors:
Samei, Ehsan et al.
Affiliation:
Duke University · United States
Species:
rodent

Abstract

A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/20011244/