Peer-reviewed veterinary case report
Methaemoglobinaemia caused by hydroxycarbamide (hydroxyurea) ingestion in a dog.
- Journal:
- The Journal of small animal practice
- Year:
- 2008
- Authors:
- Wray, J D
- Affiliation:
- Centre for Small Animal Studies
- Species:
- dog
Abstract
A three-year-old female neutered greyhound was presented after ingestion of its owner's hydroxycarbamide (hydroxyurea) tablets. The dog was found to be cyanosed, and methaemoglobinaemia was demonstrated by co-oximetry. Therapy included methylene blue, oxygen, packed red blood cell transfusion, N-acetylcysteine and crystalloid fluids. Methaemoglobinaemia resolved within 16 hours. Granulocyte colony-stimulating factor was administered for five days in an attempt to prevent severe neutropenia. Mild delayed transient myelotoxicity was suspected. The dog made a full recovery.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17850274/