Peer-reviewed veterinary case report
Meningioma and associated cerebral infarction in three dogs.
- Journal:
- BMC veterinary research
- Year:
- 2020
- Authors:
- Frank, Lisa et al.
- Affiliation:
- Department of Small Animal Medicine and Surgery · Germany
- Species:
- dog
Plain-English summary
Three dogs were diagnosed with meningiomas, which are tumors that can affect the brain and often lead to seizures. These dogs had been experiencing ongoing seizures and suddenly showed signs of neurological problems, like weakness or difficulty moving. Imaging tests showed that they had significant brain lesions, and in two of the dogs, a post-mortem examination revealed the presence of the tumor along with signs of brain damage due to a lack of blood flow. In the third dog, treatment helped improve their condition, allowing them to have a better quality of life. Overall, these cases suggest that meningiomas can lead to sudden worsening of symptoms due to complications like brain damage from reduced blood supply.
Abstract
BACKGROUND: In dogs, meningiomas mostly cause chronic progressive clinical signs due to slow tumor growth. CASE PRESENTATION: In contrast, three dogs were presented with the history of chronic generalized tonic-clonic seizures and peracute deterioration with sudden onset of neurological deficits in accordance with an extensive unilateral forebrain lesion. Magnetic resonance imaging examinations of the dogs revealed a well-delineated extraaxial T2W hyperintense mass in the rostral forebrain with homogeneous contrast enhancement. Additionally, an intraaxial, well-demarcated, unilateral lesion was apparent in the parenchyma supplied by the middle cerebral artery. In two cases, necropsy revealed meningothelial meningioma in the rostral fossa and marked eosinophilic neuronal necrosis, a sign of ischemia, focal malacia, edema and gliosis in the temporal lobe and hippocampus because of a focal thrombosis of the middle cerebral artery. In the third case symptomatic treatment resulted in improvement of clinical signs enabling a good quality of life for the patient. CONCLUSIONS: In dogs with structural epilepsy caused by meningioma, acute deterioration of clinical signs can be associated with ischemic infarctions as a potential complication.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32503537/