Peer-reviewed veterinary case report
Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury.
- Journal:
- Brain research
- Year:
- 2010
- Authors:
- Fee, Dominic B et al.
- Affiliation:
- Department of Neurology · United States
- Species:
- rodent
Abstract
Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/kg or 100mg/kg supplementation. The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20420812/