Peer-reviewed veterinary case report
Mast cell tumors in cats: clinical update and possible new treatment avenues.
- Journal:
- Journal of feline medicine and surgery
- Year:
- 2013
- Authors:
- Henry, Carolyn & Herrera, Chamisa
- Affiliation:
- University of Missouri · United States
- Species:
- cat
Plain-English summary
Mast cell tumors (MCTs) are a common type of tumor found in cats, particularly in the spleen, skin, and intestines. Diagnosing these tumors is usually straightforward, but predicting how they will behave can be tricky because their behavior varies depending on where they are located in the body. Unlike dogs, where there is a clear grading system to help understand the prognosis, cats do not have such a system, making it harder for vets to give a clear outlook. Recently, new medications called receptor tyrosine kinase inhibitors have been introduced, which may offer better treatment options for these tumors. Overall, while there is still much to learn, there are promising new avenues for treating mast cell tumors in cats.
Abstract
PRACTICAL RELEVANCE: Feline mast cell tumors (MCTs) are frequently encountered in general practice. MCTs are the most common splenic tumor, second most common skin tumor and third most common intestinal tumor in cats. Treatment and prognosis can vary dramatically with location and histologic classification. CLINICAL CHALLENGES: While a cytologic or histologic diagnosis is often easy to obtain, the various histologic classifications, lack of a relevant grading scheme, and disparity in behavior depending on anatomic location make prognostication for cases of feline MCTs confusing. This is quite different from canine MCTs, where there is an established grading system which correlates clinically with prognosis and an accepted standard of care. AUDIENCE: Due to its prevalence, general practitioners encounter MCTs regularly. In many instances, referral for diagnosis and treatment is not necessary. EVIDENCE BASE: Historically, there has been limited clinical evidence upon which to determine optimal treatment of MCTs in cats. Most recommendations are based on limited case reports or retrospective studies. With the recent introduction of receptor tyrosine kinase inhibitors to the veterinary market, there has been new research on the use of these drugs in cats, and new treatment options are on the horizon.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23254240/