Peer-reviewed veterinary case report
Mass-dependent decline of skeletal muscle function in cancer cachexia.
- Journal:
- Muscle & nerve
- Year:
- 2006
- Authors:
- Gorselink, Marchel et al.
- Affiliation:
- Department of BioMedical Research · Netherlands
- Species:
- rodent
Abstract
CD2F1 mice were inoculated with C26 adenocarcinoma cells, followed by assessment of ex vivo muscular function. Muscles from tumor-bearing mice had a significantly lower force output during a single maximal contraction and during repeated contractions than control muscles. The relative force output, however, did not differ when corrected for muscle mass. Thus, cachexia significantly reduces absolute skeletal muscle function, but muscle "quality" appears unaltered.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16372346/