Magnesium Sulfate Attenuates Lethality and Oxidative Damage Induced by Different Models of Hypoxia in Mice.

Abstract

Mgis an important cation in our body. It is an essential cofactor for many enzymes. Despite many works, nothing is known about the protective effects of MgSOagainst hypoxia-induced lethality and oxidative damage in brain mitochondria. In this study, antihypoxic and antioxidative activities of MgSOwere evaluated by three experimental models of induced hypoxia (asphyctic, haemic, and circulatory) in mice. Mitochondria protective effects of MgSOwere evaluated in mouse brain after induction of different models of hypoxia. Antihypoxic activity was especially pronounced in asphyctic hypoxia, where MgSOat dose 600&#x2009;mg/kg showed the same activity as phenytoin, which used as a positive control (< 0.001). In the haemic model, MgSOat all used doses significantly prolonged latency of death. In circulatory hypoxia, MgSO(600&#x2009;mg/kg) doubles the survival time. MgSOsignificantly decreased lipid peroxidation and protein carbonyl and improved mitochondrial function and glutathione content in brain mitochondria compared to the control groups. The results obtained in this study showed that MgSOadministration has protective effects against lethality induced by different models of hypoxia and improves brain mitochondria oxidative damage.