Peer-reviewed veterinary case report
Lung Cancer Murine Models and Methodology for Immunopreventive Study.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2022
- Authors:
- Ramos-Castaneda, Marco & Moghaddam, Seyed Javad
- Affiliation:
- Department of Pulmonary Medicine · United States
Abstract
Lung cancer is the second most common cancers in the world and remains as the cancer with the highest incidence of death (Siegel et al. CA Cancer J Clin 71(1):7-33, 2021). K-RAS mutation is one of the most common mutations in non-small-cell lung cancer (NSCLC), encompassing 15-30% of lung adenocarcinomas (Cancer Genome Atlas Research Network. Nature 511:543-550, 2014). In this chapter, we describe various murine models with the goal of studying the role of inflammation in development and promotion of lung cancer. Immunomodulatory strategies are described in detail as well as the protocols that follow the intervention for harvesting various tissue and fluids for immune-profiling.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34993949/