Long-term supplementation with an undenatured type-II collagen (UC-II) formulation in dogs with degenerative joint disease: Exploratory study.

Abstract

BACKGROUND: Undenatured type-II collagen (UC-II) has demonstrated its benefits in degenerative joint disease (DJD) management. AIM: Exploratory clinical study to investigate the beneficial effects of FLEXADINAdvanced in dogs. METHODS: Multicentre clinical prospective study, 110 client-owned dogs with a clinical diagnosis of DJD. Dogs received FLEXADINAdvanced during 6 months. Pain, general condition, appetite, mobility, and lameness were assessed monthly by veterinarians and owners for 6 months. Compliance was assessed at 3 and 6 months. Statistical analysis was performed with non-parametric tests (significance,< 0.05). RESULTS: Parameters assessed were significantly lower comparing inclusion with all subsequent months (< 0.0001). Compliance at 3 months showed a good score but was significantly lower (< 0.0001) at 6 months. CONCLUSION: FLEXADINAdvanced, containing UC-II, can be considered as a good complementary feed to provide joint support in dogs with mild to moderate DJD.