Peer-reviewed veterinary case report
Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2006
- Authors:
- Alenza, Dolores Perez et al.
- Affiliation:
- Veterinary Teaching Hospital · Spain
- Species:
- dog
Abstract
Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16822765/