Peer-reviewed veterinary case report
Long-term effects of melatonin after intracerebral hemorrhage in rats.
- Journal:
- Acta neurochirurgica. Supplement
- Year:
- 2008
- Authors:
- Hartman, R E et al.
- Affiliation:
- Department of Psychology · United States
- Species:
- rodent
Abstract
Free radical scavengers have been shown to improve short-term outcome after intracerebral hemorrhage (ICH). The purpose of this study was to evaluate whether melatonin (a potent free radical scavenger and an indirect antioxidant) can improve short- and/or long-term neurological function after ICH, which was induced by collagenase injection into the striatum of adult rats. Melatonin (15 mg/kg) was administered by intraperitoneal injection at 1, 24, 48, and 72 h. Neurological and behavioral testing was performed at several time points from 1 day to 8 weeks post-ICH. Neurological and behavioral deficits were observed in ICH rats at all time points, but the melatonin treatment regimen did not improve performance or level of brain injury.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19066091/