Peer-reviewed veterinary case report
Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide.
- Journal:
- Journal of pharmacological sciences
- Year:
- 2015
- Authors:
- Dogishi, Koji et al.
- Affiliation:
- Department of Molecular Pharmacology · Japan
- Species:
- rodent
Abstract
We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26685753/