Peer-reviewed veterinary case report
Locomotion analysis of Sprague-Dawley rats before and after injecting 6-OHDA.
- Journal:
- Behavioural brain research
- Year:
- 2010
- Authors:
- Tang, Wenlong et al.
- Affiliation:
- Department of Mechanical Engineering · United States
- Species:
- rodent
Abstract
The hypothesis that changes in measured ground reaction forces and time parameters during locomotion can noninvasively detect Parkinsonism in unilateral 6-OH dopamine (6-OHDA) lesioned rats is tested. It was found that changes of seven locomotion parameters can be used to construct a logistic regression model with a detection sensitivity and specificity of over 90% as compared to non-lesioned rats. Comparisons between this model and other neurological and neuromuscular disorders are presented.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20153780/