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Peer-reviewed veterinary case report

Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock.

Journal:
Methods in molecular biology (Clifton, N.J.)
Year:
2018
Authors:
Møller-Helgestad, Ole K et al.
Affiliation:
Department of Cardiology

Abstract

Cardiogenic shock is one of the leading causes of death following acute myocardial infarction affecting 10% of patients with large myocardial infarcts with a subsequent mortality rate of 50%. Here we describe a large porcine model of acute ischemic cardiogenic shock. Acute left or right ventricular failure can be achieved with close to a 100% success rate by stepwise injection of microspheres into the left or right coronary artery, respectively, and the method allows for titration of heart failure to a prespecified level.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/29987833/