Peer-reviewed veterinary case report
Isolation and Phenotyping of Splenic Myeloid-Derived Suppressor Cells in Murine Cancer Models.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2021
- Authors:
- Sanseviero, Emilio et al.
- Affiliation:
- The Wistar Institute · United States
Abstract
Myeloid-derived suppressor cells (MDSC) are immunosuppressive myeloid cells that accumulate in tumor sites and peripheral lymphoid organs such as the spleen. In murine cancer models, the spleen is a major reservoir for MDSC, representing an easily accessible tissue from which to isolate high numbers of these cell population for downstream applications. Here we describe an efficient method to phenotype as well as to isolate and assess the functionality of murine splenic MDSC.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33237537/