Peer-reviewed veterinary case report
Intrinsic (Genetic) Aerobic Fitness Impacts Susceptibility for Metabolic Disease.
- Journal:
- Exercise and sport sciences reviews
- Year:
- 2017
- Authors:
- Thyfault, John P & Morris, E Matthew
- Affiliation:
- University of Kansas Medical Center
- Species:
- rodent
Abstract
Low capacity runner (LCR) and high capacity runner (HCR) rat strains are divergent for running capacity and aerobic fitness. The LCR rats are susceptible to obesity, insulin resistance, and fatty liver while the HCR are protected. We performed studies testing the hypothesis that the divergence in susceptibility for obesity and metabolic dysfunction between HCR/LCR is due to differences in hepatic mitochondrial function that may also drive differences in energy expenditure and substrate utilization.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27433978/