Peer-reviewed veterinary case report
Intestinal T-cell lymphoma with severe hypereosinophilic syndrome in a cat.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2012
- Authors:
- Takeuchi, Yoshinori et al.
- Affiliation:
- Department of Veterinary Internal Medicine · Japan
- Species:
- cat
Plain-English summary
An 8-year-old Japanese domestic long-hair cat was brought to the vet because it was vomiting and had blood in its stool. Tests showed that the cat had a high number of a type of white blood cell called eosinophils. Initially, the cat was treated with a medication called prednisolone and seemed to be doing okay, but after about 17 months, it started vomiting blood, lost weight, and stopped eating. Unfortunately, the cat developed a serious condition where the intestine ruptured and passed away shortly after. The final examination confirmed that the cat had intestinal T-cell lymphoma (a type of cancer) along with severe hypereosinophilic syndrome.
Abstract
A Japanese domestic long-hair cat of about 8 years of age was presented with vomiting and hematochezia and was found to have significant hypereosinophilia. Bone marrow aspiration revealed moderate increases of eosinophilic lineages. Histopathological examination revealed mild eosinophilic and epitheliotropic T-lymphocytic infiltrations in the duodenum. Although the cat remained asymptomatic with only prednisolone administration, the cat presented with hematemesis, weight loss, and severe anorexia 512 days after the initial presentation. Subsequently, gastrointestinal perforation developed, and the cat died on Day 536. Histopathological examination of autopsy specimens revealed mixed cellular infiltration including eosinophils and neoplastic lymphocytes in the intestinal lymph nodes, intestine, liver, spleen, and pancreas. Immunohistochemical examination supports a diagnosis of intestinal T-cell lymphoma with severe hypereosinophilic syndrome.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22452876/