Peer-reviewed veterinary case report
Inflammatory cytokine and C-reactive protein concentrations in dogs with systemic inflammatory response syndrome.
- Journal:
- Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
- Year:
- 2018
- Authors:
- Gommeren, Kris et al.
- Affiliation:
- Department of Clinical Sciences
- Species:
- dog
Plain-English summary
This study looked at 69 dogs with systemic inflammatory response syndrome (SIRS), a serious condition where the body has a strong inflammatory reaction. Researchers measured levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) at various times during their hospital stay. They found that most dogs had high CRP levels when they first arrived, but these levels decreased as treatment continued, and most dogs had normal levels by their follow-up visit a month later. However, the levels of these proteins did not help predict how well the dogs would do overall. In the end, 44 dogs survived, while 8 died and 17 were euthanized.
Abstract
OBJECTIVE: To evaluate C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) kinetics in dogs with a systemic inflammatory response syndrome (SIRS) presented to an emergency service. We hypothesized serum CRP concentrations would increase and vary during hospitalization, and would correlate with plasma IL-6 and TNF-α concentrations, vary in magnitude according to the underlying disease, and predict survival. DESIGN: Prospective, observational, clinical study. SETTING: University emergency department. ANIMALS: Sixty-nine dogs with SIRS weighing over 5 kg who could tolerate the blood sampling. INTERVENTIONS: Serum and plasma were collected (and stored at -80°C) at presentation (T0), after 6 (T6), 12 (T12), 24 (T24), and 72 (T72) hours, and at a follow-up visit at least 1 month after discharge (T1m). Underlying diseases were categorized as infection (I), neoplasia (N), trauma (T), gastric-dilation and volvulus (GDV), other gastrointestinal (GI), renal (R), and miscellaneous (M) disease. MEASUREMENTS AND MAIN RESULTS: Serum CRP concentration was measured using a canine-specific immunoturbidimetric assay. Biologically active plasma IL-6 and TNF-α concentrations were assessed using bioassays. Forty-four dogs survived, 8 died, and 17 were euthanized. Nineteen dogs had follow-up visits. At T0, serum CRP concentration was above the reference interval in 73.1% (49/67), and was within the reference interval (0-141.9 nmol/L) throughout hospitalization in only 6% (4/67). Serum CRP concentrations were significantly higher (P < 0.0001) at T0 (882.9 ± 1082.9 nmol/L) and at all time points during hospitalization (P < 0.0001) compared to T1m, with highest concentrations observed at T24 (906. 7 ± 859.0 nmol/L). At T1m, serum CRP concentrations were within the reference interval (22.9 ± 42.9 nmol/L) in 95% (18/19) of dogs. Logarithmic concentrations of serum CRP and plasma IL-6 were significantly correlated (P < 0.001, r = 0.479). None of the measured cytokines were associated with disease category or outcome. CONCLUSIONS: Serum CRP concentration is increased in dogs with SIRS, and decreases during treatment and hospitalization. Serum CRP, plasma IL-6, and plasma TNF-α concentrations cannot predict outcome in dogs with SIRS.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29236338/