Peer-reviewed veterinary case report
Induction of passive EAE using myelin-reactive CD4+ T cells.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2014
- Authors:
- McPherson, Rhoanne C et al.
- Affiliation:
- Queen's Medical Research Institute · United Kingdom
- Species:
- rodent
Abstract
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease of the central nervous system (CNS) often used as a model for the early inflammatory stages of multiple sclerosis and also as a model of organ-specific autoimmune disease.This protocol describes the induction of passive EAE in mice, either using T cells isolated from mice primed with myelin antigens, or through the use of naïve TCR transgenic T cells activated in vitro in the presence of myelin-derived antigens.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25151007/