Peer-reviewed veterinary case report
Induction of colitis in mice (T-cell transfer model).
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2014
- Authors:
- Weigmann, Benno
- Affiliation:
- Medical Clinic I · Germany
- Species:
- rodent
Abstract
Animal model of intestinal inflammation is essential for the understanding of the pathomechanisms of inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Typically, naïve T-cells were transferred into immunocompromised mice and develop gut inflammation because of inappropriate downregulation. Here, we describe the isolation, purification, and transfer of CD4(+)CD25(-) T-cells into recipients to obtain an experimental colitis model for the analysis of pathogenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25151004/