Peer-reviewed veterinary case report
Increased oxidative-related mechanisms in the spinal cord injury in old rats.
- Journal:
- Neuroscience letters
- Year:
- 2006
- Authors:
- Genovese, Tiziana et al.
- Affiliation:
- Department of Clinical and Experimental Medicine and Pharmacology · Italy
- Species:
- rodent
Abstract
In the present study, we evaluated the effect of age, in a model of spinal cord injury that was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in old rats resulted in severe trauma characterized by edema and neutrophil infiltration. Immunohistochemical examination demonstrated an increase in immunoreactivity for nitrotyrosine. In contrast, the degree of: (a) spinal cord inflammation and tissue injury (histological score), (b) nitrotyrosine, (c) PARS, and (d) neutrophils infiltration was markedly reduced in spinal cord tissue obtained from young rats. We have also demonstrated that ageing significantly worsened the recovery of limb function and caused an increase in mortality rate when compared with young rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16236449/