Peer-reviewed veterinary case report
Incidence and genetic aspects of patellar luxation in Pomeranian dogs in Thailand.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2013
- Authors:
- Soontornvipart, K et al.
- Affiliation:
- Department of Veterinary Surgery
- Species:
- dog
Abstract
There is a high incidence of patellar luxation (PL) in Pomeranian dogs from Thailand. DNA samples were collected from 59 dogs originating from 15 families. PL was present in 75% of the dogs with a male:female ratio of 1:1.95. Polymorphic microsatellites situated close to the COL6A1, COL6A3, COL9A1, COL9A2, and COL9A3 genes were analyzed for linkage to the phenotype. Sibling-pair analysis revealed that none of the collagen markers analyzed had a high non-parametric linkage score with the highest score, 1.56, for COL9A2 (P=0.07). The low LOD scores for these collagen genes indicated a non-involvement in the pathogenesis of PL in Pomeranians. An association study with a low density single nucleotide polymorphism (SNP) set indicated the possible involvement of a region on chromosome 7. The association of this region remained indicative when larger groups of 43 cases and 40 controls were compared (Chi square test P=0.01).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22939087/