Peer-reviewed veterinary case report
Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2011
- Authors:
- Glaser, Matthias et al.
- Affiliation:
- Hammersmith Hospital · United Kingdom
- Species:
- rodent
Abstract
We improved the specific radioactivity of the apoptosis imaging isatin derivative (18)F-ICMT11. We then evaluated (18)F-ICMT11 in EL4 tumor-bearing mice 24h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115±0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083±0.008 SUV). This effect correlated to the observed increases in apoptotic index.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22030029/