Peer-reviewed veterinary case report
Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course.
- Journal:
- Retrovirology
- Year:
- 2008
- Authors:
- Freer, Giulia et al.
- Affiliation:
- Department of Experimental Pathology · Italy
- Species:
- cat
Abstract
Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18416857/