Peer-reviewed veterinary case report
Immunohistochemical studies on meningoencephalitis in feline infectious peritonitis (FIP).
- Journal:
- The Journal of veterinary medical science
- Year:
- 2018
- Authors:
- Wang, Huanan et al.
- Affiliation:
- Graduate School of Agricultural and Life Sciences · Japan
- Species:
- cat
Abstract
The present study describes the association between inflammatory cell types and feline infectious peritonitis virus (FIPV) antigen in the brain of 4 cats diagnosed as feline infectious peritonitis (FIP). Immunohistochemically, FIPV antigens were detected in the inflammatory foci of the leptomeninges, choroid plexus and ventricles in 3 of the 4 cats. In 3 cases, inflammatory foci mainly consisted of CD204- and Iba1-positive macrophages, and the FIPV antigens were found in the macrophages. In the other case which was negative for FIPV antigen, severe inflammation predominantly consisting of CD20-positive B lymphocytes was observed in the leptomeninges and subventricles, accompanied with diffuse proliferation of gemistocytic astrocytes. The difference in histopathology may reflect the inflammatory process or the strain variation of FIP virus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30333381/