Peer-reviewed veterinary case report
Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas.
- Journal:
- Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
- Year:
- 2007
- Authors:
- Borzacchiello, G et al.
- Affiliation:
- Department of Pathology and Animal Health · Italy
- Species:
- dog
Abstract
Ovarian tumours among domestic animals are frequently encountered in bitch. Cyclooxygenase-2 (COX-2) expression has been evaluated in different kind of canine primary epithelial neoplasms. Eleven canine ovarian carcinomas and two normal samples were evaluated immunohistochemically for COX-2 expression. Nine of 11 carcinoma samples (81%) expressed COX-2 enzyme isoform. The immunoreactivity was intracytoplasmically recorded and the intensity ranged from faint to strong. Our results show that COX-2 is expressed in canine ovarian carcinoma, suggesting a potential role of COX-2 in canine ovarian carcinogenesis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17523957/