Peer-reviewed veterinary case report
Immunogenicity of recombinant measles vaccine expressing fusion protein of respiratory syncytial virus in cynomolgus monkeys.
- Journal:
- Microbiology and immunology
- Year:
- 2018
- Authors:
- Sawada, Akihito et al.
- Affiliation:
- Kitasato Institute for Life Sciences · Japan
- Species:
- rodent
Abstract
Respiratory syncytial virus (RSV) is a common cause of respiratory infections in infants. Effective vaccines are currently being sought, but no vaccine is thus far available. In our previous study, recombinant AIK-C measles vaccine expressing the RSV fusion protein (MVAIK/RSV/F) was developed and protective immunity against RSV demonstrated in cotton rats. In the present study, the immunogenicity and protective effects were investigated in three cynomolgus monkeys immunized with MVAIK/RSV/F. Neutralizing test antibodies against RSV were detected and no infectious virus was recovered from the lungs of monkeys immunized with MVAIK/RSV/F after challenge. MVAIK/RSV/F has the potential to inhibit RSV infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29194753/