Peer-reviewed veterinary case report
Hyperbaric oxygenation attenuates renal ischemia-reperfusion injury in rats.
- Journal:
- Transplantation proceedings
- Year:
- 2006
- Authors:
- Gurer, A et al.
- Affiliation:
- Department of Surgery
- Species:
- rodent
Abstract
BACKGROUND: Oxygen-derived free radicals play an important role in ischemia-reperfusion injury (IR). Hyperbaric oxygenation (HO) decreases free radical production. The aim of this study was to determine the effect of HO treatment on renal ischemia-reperfusion injury in rats. METHODS: Rats were divided into four groups. All groups underwent right nephrectomy. Group I served as the control group; group II had left renal ischemia-reperfusion; group III was pretreated with HO; and group IV, ischemia-reperfusion and HO pretreatment. Tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured, and histopathologic damage scored. RESULTS: HO pretreatment significantly decreased tissue MDA levels and histopathologic scores among rats with IR. There was an increased GSH in HO-pretreated rats with IR; however, the difference was not significant. CONCLUSION: HO prior to ischemia displayed a beneficial effect on renal IR by reducing oxygen radical peroxidation of lipid membranes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17175266/