Peer-reviewed veterinary case report
Histopathological and Immunophenotypical Analysis of Canine Mucinous Rectal Adenocarcinoma
- Journal:
- Brazilian Journal of Veterinary Pathology
- Year:
- 2012
- Authors:
- Karine Araújo Damasceno et al.
- Affiliation:
- Programa de Pós-Graduação em Patologia da UFMG, Laboratório de Patologia Comparada, Depto. de Patologia Geral - ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. · BR
- Species:
- dog
Abstract
Rectal adenocarcinomas are uncommon in dogs and usually present poor prognosis. The present work describes the morphological and immunophenotypical findings of a rectal mucinous adenocarcinoma in a bitch. Histological analysis revealed a malignant epithelial proliferation in a tubulopapillary pattern forming multiple intratubular cell layers. Moderate amount of PAS-positive amorphous eosinophilic content within neoplastic tubules and extruded into the stroma was observed. Immunohistochemical analysis revealed neoplastic cells considered positive for cytokeratin, Her-2, COX-2 and E-caderin and with low p53 expression. A high proliferation index was observed. Based on histological and immunophenotypical findings, the diagnosis of mucinous adenocarcinoma was established.
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Search related cases →Original publication: https://doi.org/10.24070/bjvp.1983-0246.005013