Peer-reviewed veterinary case report
Histiocytic typhlocolitis in two colony Beagle dogs.
- Journal:
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
- Year:
- 2015
- Authors:
- Carvallo, Francisco R et al.
- Affiliation:
- California Animal Health and Food Safety Laboratory · United States
- Species:
- dog
Plain-English summary
Two young female Beagle dogs from a research facility were found to have a condition called histiocytic ulcerative colitis, which is a type of inflammatory bowel disease that causes loose stools and blood in the feces. This condition is more commonly seen in certain breeds like Boxers and French Bulldogs. Tests on one of the dogs showed the presence of a specific strain of E. coli bacteria, which has been linked to similar bowel issues in other dogs. It's important to distinguish this natural condition from any effects caused by experimental treatments in research settings. The study highlights the need for careful diagnosis and understanding of this disease in Beagle dogs.
Abstract
Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog demonstrated the presence of Escherichia coli strain LF82 by immunohistochemistry and 16S ribosomal RNA gene sequencing. E coli strain LF82 has been implicated in the pathogenesis of Crohn's disease and similar bacteria have been cultured from cases of histiocytic ulcerative colitis in Boxer dogs. Spontaneous histiocytic ulcerative colitis must be differentiated from test article-related findings in nonclinical toxicity studies in Beagle dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25467750/