Peer-reviewed veterinary case report
Highly pathogenic avian influenza A(H5N1) virus infection in foxes with PB2-M535I identified as a novel mammalian adaptation, Northern Ireland, July 2023.
- Journal:
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- Year:
- 2023
- Authors:
- Lagan, Paula et al.
- Affiliation:
- Agri-Food and Biosciences Institute (AFBI) Belfast
- Species:
- bird
Abstract
We report cases of mammalian infection with highly pathogenic avian influenza (HPAI) virus A(H5N1) clade 2.3.4.4b in Northern Ireland. Two common gulls () and two red fox kits (), were found dead in close vicinity. Comparison of viral whole genome sequences obtained from the animals identified a novel mammalian adaptation, PB2-M535I. Analysis of genetic sequences from other recent mammalian infections shows that this mutation has arisen on at least five occasions in three European countries since April 2023.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37855904/