Peer-reviewed veterinary case report
HER2 Overexpression and Amplification in Feline Pulmonary Carcinoma.
- Journal:
- Veterinary pathology
- Year:
- 2021
- Authors:
- Muscatello, Luisa Vera et al.
- Affiliation:
- 9296University of Bologna · Italy
- Species:
- cat
Abstract
HER2 is overexpressed, amplified, and mutated in a subset of human lung cancer. The aim of this study was to investigate HER2 protein overexpression and gene amplification in feline pulmonary carcinomas. Thirteen pulmonary carcinomas were selected and TTF-1 and HER2 expression was evaluated by immunohistochemistry. Fluorescence in situ hybridization (FISH) was performed with aprobe and a BAC probe for the feline chromosome E1p1.12-p1.11 region. Twelve adenocarcinomas and 1 squamous cell carcinoma were diagnosed. TTF-1 was positive in 7 carcinomas (58%). HER2 was overexpressed in 2 (15%), equivocal in 5 (38%), and negative in 6 cases (46%). FISH analysis ofwas indeterminate in 2 cases. Three pulmonary carcinomas (27%) hadamplification and 8 cases were not amplified (73%). The significant correlation between HER2 protein overexpression and gene amplification are promising preliminary data, but study of additional cases is needed to confirm HER2 as a target for possible innovative treatments.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33461438/