Peer-reviewed veterinary case report
Hemostatic abnormalities in dogs with primary immune-mediated hemolytic anemia.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2001
- Authors:
- Scott-Moncrieff, J C et al.
- Affiliation:
- Department of Veterinary Clinical Sciences · United States
- Species:
- dog
Plain-English summary
In a study involving 20 dogs diagnosed with primary immune-mediated hemolytic anemia, researchers looked at various blood clotting factors. Some of these dogs had previously been treated with prednisone, a medication that can affect the immune system. They found that many of the dogs had issues with their blood clotting, including increased times for certain tests and higher levels of specific proteins that indicate clotting problems. Nine dogs showed signs of a serious condition called disseminated intravascular coagulation (DIC), which can lead to dangerous blood clots. Unfortunately, thromboembolism, which is when a blood clot travels to the lungs or other organs, was common in the dogs that passed away, but the study did not find a clear link between death and specific symptoms or lab results.
Abstract
Hemostatic parameters were prospectively measured in 20 dogs with primary immune-mediated hemolytic anemia. Eight of 20 dogs had received prior treatment with prednisone. Activated partial thromboplastin time was increased in nine dogs; one-stage prothrombin time was increased in two dogs; fibrinogen concentration was increased in 17 dogs; and antithrombin activity was decreased in 10 dogs. Fibrin(ogen) degradation products concentration was increased in 12 dogs, and D-dimer concentration was increased in 16 dogs. Four or more laboratory criteria of disseminated intravascular coagulation (DIC) were present in nine dogs, and three criteria of DIC were found in four additional dogs. Thromboembolism was the most common finding in the dogs that died. In this study population, mortality was not significantly associated with any clinical finding or laboratory variable.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/11361112/