Peer-reviewed veterinary case report
Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2011
- Authors:
- Kornegay, Joe N et al.
- Affiliation:
- Department of Pathology and Laboratory Medicine and The Gene Therapy Center · United States
- Species:
- dog
Abstract
Studies of canine models of Duchenne muscular dystrophy (DMD) provide insight regarding disease pathogenesis and treatment efficacy. To take maximal advantage, colonies of affected dogs must be maintained and outcome parameters developed. In this chapter, we review our 25 years of experience with the golden retriever muscular dystrophy (GRMD) model. Key challenges in colony development (breeding, neonatal death, and the risk of inbreeding) and representative functional measurements (tibiotarsal joint angle and torque force; and eccentric contraction decrement) are discussed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21194024/