Peer-reviewed veterinary case report
Gliomatosis Cerebri in a Dog
- Journal:
- Brazilian Journal of Veterinary Pathology
- Year:
- 2011
- Authors:
- Sant’Ana, Fabiano J. F. de & Barros, Claudio S. L.
- Species:
- dog
Plain-English summary
A 6-year-old female mixed-breed dog was examined after she showed signs of being very tired, having trouble with coordination, circling to the right, and experiencing seizures. When the brain was looked at closely after her passing, no obvious problems were seen, but there were many abnormal glial cells (a type of brain cell) found in several areas of her brain. These abnormal cells were also present in the protective layers around the brain and in the white matter of the cerebellum, which is involved in movement. The specific tests used to analyze these cells helped confirm a diagnosis of gliomatosis cerebri, a type of brain tumor. Unfortunately, the outcome was not favorable, as the condition was serious and led to her death.
Abstract
A 6-year-old, female, mixed-breed dog was presented for necropsy with history of prostration and incoordination followed by circling to the right and seizures. There were no gross findings in the brain. Histologically, there were numerous neoplastic glial cells throughout the thalamus, midbrain, pons and medulla oblongata. Moderate multifocal lymphoplasmacytic perivascular cuffings were also present in the same areas. In addition, severe multifocal proliferation of glial cells was observed in the leptomeninge and white matter of the cerebellum. The neoplastic cells observed in the brain stem were negative for GFAP, while in the cerebellum the neoplastic glial cells were strongly labeled with GFAP and vimentin. Based on the histopathological findings and on the immunohistochemical results, a diagnosis of gliomatosis cerebri was made.
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Search related cases →Original publication: https://doi.org/10.24070/bjvp.1983-0246.004011