Peer-reviewed veterinary case report
Glioblastoma Multiforme with Hypodipsic Hypernatremia in a Seven-Month-Old Golden Retriever.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2016
- Authors:
- Engel, Stephanie et al.
- Affiliation:
- From the Clinical Sciences Department (S.E.) · United States
- Species:
- dog
Plain-English summary
A seven-month-old Golden Retriever was diagnosed with a rare condition called hypodipsic hypernatremia, which means the dog wasn't feeling thirsty and had high sodium levels in the blood. This condition can be caused by various issues, including brain tumors, and in this case, the dog had a type of brain tumor known as glioblastoma multiforme, which is unusual for such a young dog. The tumor likely damaged the part of the brain that controls thirst, leading to the dog's symptoms. This situation is quite rare, especially since it involved a tumor from glial cells, which are supportive cells in the brain. The treatment details and outcome were not provided in the abstract.
Abstract
Primary hypodipsic hypernatremia is a rarely reported disease in dogs. Reported underlying causes associated with this disease in dogs include congenital malformations, encephalitis, intracranial neoplasia, and pressure atrophy of the hypothalamus secondary to hydrocephalus. The dog in this report had an infiltrative neoplastic disorder, likely causing damage to the hypothalamic osmoreceptors responsible for the thirst generation. The neoplastic process was identified histopathologically as glioblastoma multiforme, an unusual tumor to occur in a dog this young. A tumor of the central nervous system causing physical destruction of the osmoreceptors has rarely been reported in dogs and none of the previously reported cases involved a glial cell tumor.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27487344/