Peer-reviewed veterinary case report
Gentamicin toxic nephropathy in horses with disseminated bacterial infection.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1982
- Authors:
- Riviere, J E et al.
- Species:
- horse
Plain-English summary
In this study, three young horses developed kidney problems due to gentamicin, an antibiotic. The signs of kidney damage included higher levels of urea in their blood and abnormal substances in their urine, but there were no signs of infection in the urine. All horses had received the recommended doses of gentamicin. In one case, the kidney issue was caught early, and the horse improved after stopping the medication and increasing fluid intake. Overall, the treatment worked in that case, but it’s important to monitor for these side effects when using gentamicin.
Abstract
Three clinical cases of toxic nephropathy in young horses were ascribed to gentamicin toxicity. Criteria for defining gentamicin-induced nephrotoxicosis were a serum urea nitrogen value greater than the pretreatment value or cylindruria, hematuria, and proteinuria in the absence of pyuria and bacteriuria. Recommended doses of gentamicin had been given in all cases. The nephropathy was reversible in 1 case in which the toxicosis was detected early and was treated by volume diuresis and drug withdrawal.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/7068505/