Peer-reviewed veterinary case report
Genome-wide association study for antibody response to Mycobacterium avium ssp. paratubeculosis in goats.
- Journal:
- Animal genetics
- Year:
- 2023
- Authors:
- Minozzi, Giulietta et al.
- Affiliation:
- Department of Veterinary Medicine and Animal Sciences · Italy
Abstract
Mycobacterium avium ssp. paratuberculosis (MAP), causes Johne's disease (JD), or paratuberculosis, a chronic enteritis of ruminants, which in goats is characterized by ileal lesions. The work described here is a case-control association study using the Illumina Caprine SNP50 BeadChip to unravel the genes involved in susceptibility of goats to JD. Goats in herds with a high occurrence of Johne's disease were classified as healthy or infected based on the level of serum antibodies against MAP, and 331 animals were selected for the association study. Goats belonged to the Jonica (157) and Siriana breeds (174). Whole-genome association analysis identified one region suggestive of significance associated with an antibody response to MAP on chromosome 7 (p-value = 1.23 × 10). These results provide evidence for genetic loci involved in the antibody response to MAP in goats.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36321295/