Peer-reviewed veterinary case report
Genetically modified mice-successes and failures of a widely used technology.
- Journal:
- Pflugers Archiv : European journal of physiology
- Year:
- 2010
- Authors:
- Castrop, Hayo
- Affiliation:
- Institute of Physiology · Germany
- Species:
- rodent
Abstract
Genetically modified mice, created by random integration of a transgene into the genome or by targeted mutation of a specific gene, have proven to be extremely powerful tools for studying gene function in vivo. In this article, we give (1) a short overview of the traditional methods in mouse transgenesis and (2) a discussion of the problems with these methods, (3) more recent methods that were developed to overcome these problems, and (4) an outlook on future directions in gene targeting.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20140450/