Peer-reviewed veterinary case report
Generation and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2019
- Authors:
- Karikari, Akua A et al.
- Affiliation:
- Department of Neurology · Germany
Abstract
The use of viral vector-mediated α-synuclein-overexpressing rodent models for Parkinson's disease has become increasingly accepted to study associated pathology and to use as a platform for therapeutic efficacy testing. We here describe methods to generate such models and how to analyze them by behavioral assessments, histological investigations, and examination of nigrostriatal dopaminergic function.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30771185/