Peer-reviewed veterinary case report
Gene expression of adrenomedullin in canine normal tissues and diseased hearts.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2009
- Authors:
- Kanno, Nobuyuki et al.
- Affiliation:
- Department of Veterinary Medicine · Japan
- Species:
- dog
Abstract
The purposes of this study were to determine the tissue distribution of canine adrenomedullin (AM) and to determine whether increased canine AM mRNA expression is associated with congestive heart failure (CHF) due to mitral regurgitation (MR). Canine AM mRNA expression was detectable in various normal tissues, including cardiovascular tissues. In addition, the AM mRNA expression in the left atrium of dogs with MR was significantly higher than that in normal subjects. In conclusion, AM is a potential neurohumoral factor in dogs with CHF due to MR.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19578289/