Peer-reviewed veterinary case report
Gastrointestinal models: intestinal transit, gastric emptying, and ulcerogenic activity in the rat.
- Journal:
- Current protocols in pharmacology
- Year:
- 2008
- Authors:
- Guillaume, Philippe et al.
- Affiliation:
- Porsolt and Partners Pharmacology · France
- Species:
- rodent
Abstract
The protocols described in this unit are designed to assess the effects of substances on intestinal transit and gastric emptying and to evaluate their ulcerogenic potential on the stomach and duodenum of the rat. Examples of results obtained with atropine or morphine (intestinal transit), loperamide (gastric emptying), or indomethacin (ulcerogenic activity) used as reference substances are provided for illustrative purposes. Atropine and morphine clearly reduce intestinal transit. Atropine, morphine, and loperamide clearly reduce gastric emptying. Indomethacin shows a marked ulcerogenic potential.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22294224/