Peer-reviewed veterinary case report
Focal myasthenia gravis as a paraneoplastic syndrome of canine thymoma: improvement following thymectomy.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 1996
- Authors:
- Lainesse, M F et al.
- Affiliation:
- Department of Veterinary Internal Medicine · Canada
- Species:
- dog
Abstract
A 10-year-old, neutered male cocker spaniel-cross experienced regurgitation, dry retching, and weight loss. A large, mediastinal mass and dilatation of the esophagus were seen on thoracic radiographs. Cytological, histopathological, immunohistochemical, and serological findings were consistent with a lymphoepithelial thymoma and focal, esophageal myasthenia gravis. Surgical removal of the mass resulted in rapid resolution of the megaesophagus and a decrease in serum acetylcholine-receptor antibody concentration. The dog was clinically normal until the thymoma recurred six months postoperatively. Clinical signs, diagnostic evaluation, management, and treatment of a dog with thymoma and megaesophagus are described.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8680916/