Peer-reviewed veterinary case report
Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2010
- Authors:
- Rullas, Joaquín et al.
- Affiliation:
- GlaxoSmithKline · Spain
- Species:
- rodent
Abstract
Murine models of Mycobacterium tuberculosis infection are essential tools in drug discovery. Here we describe a fast standardized 9-day acute assay intended to measure the efficacy of drugs against M. tuberculosis growing in the lungs of immunocompetent mice. This assay is highly reproducible, allows good throughput, and was validated for drug lead optimization using isoniazid, rifampin, ethambutol, pyrazinamide, linezolid, and moxifloxacin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20160054/