Exploration of animal models to study the life cycle of.

Abstract

The parasiteis an important zoonotic parasite. The development of an animal model of's life cycle is critical for studying the biological characteristics of the parasite in snails and mammals. Eggs ofof bovine origin were cultured, and metacercariae were obtained after infection ofsnails. The life cycle system ofwas initiated in 2 different animals by orally infecting rabbits, SD rats and Kunming mice with the metacercariae. The animals' survival after infection, parasite migration in the animals and pathological damage to the liver were observed. We discovered that rabbits died due to acute suppurative hepatitis 6069 days after infection, and eggs were found in the feces on day 63 of infection. The liver of SD rats showed punctate lesions on day 3 of infection, and further changes occurred as the infection progressed. However, liver repair was observed at week 9. SD rats survived for more than a year after infection and continued thelife cycle. The liver lesions in Kunming mice after infection were similar but more severe than those in SD rats. Death was observed on the 31st postinfection day. We discovered that while rabbits, SD rats and Kunming mice can all be used as animal models of, SD rats are more suitable experimental animals in terms of tolerance and pathological response.